Abstract TP186: Impact of Long-term Left Ventricular Assist Device Support on Human Brain: A Case-control Study Using MRI

Abstract

Introduction: Left ventricular assist device (LVAD) implantation improves the prognosis of patients with severe heart failure; however, the potential impact of long-term LVAD support on the brain remains unclear. The aim of this case-control study was to examine the characteristics of brain MRI in patients after long-term LVAD support. Methods: We retrospectively reviewed consecutive adult patients who underwent continuous-flow LVAD implantation in our hospital from 2010 to 2017, and those who underwent brain MRI after successful LVAD explantation were enrolled in this study. Age- and sex-matched control subjects (1:1) were selected from a pool of normal subjects who underwent MRI examination for screening purposes. The number and location of cerebral microbleeds (CMBs) and superficial siderosis, and the severity of white matter hyperintensity (WMH) and cerebral atrophy were compared between LVAD patients and controls. Results: We enrolled 49 LVAD patients and 49 controls. In LVAD patients, cardiomyopathy (84%) was the most common underlying heart disease. Heart transplantation was performed in 46 patients (94%) and 3 removed LVAD due to myocardial recovery. The median age was 41 years (range 19-66), and the median LVAD support time was 32 months (4-52). Nineteen patients developed symptomatic stroke (10 ischemic and 10 hemorrhagic) during LVAD support. Except for one, almost all (98%) LVAD patients had one or more CMBs, and the number of CMBs was much higher in the LVAD patients (mean, IQR: 7, 3-11 vs 0, 0-0: p<0.001) than controls. Superficial siderosis was positive in 15 (31%) of LVAD patients, but not in controls. The severity of WMH was significantly higher both in deep subcortical (p=0.01), and periventricular region (p=0.04) than controls. In quantitative analyses of cerebral atrophy, bicaudate ratio (0.105±0.023 vs 0.089±0.019: p<0.001) and cella-media index (0.160±0.033 vs 0.141±0.024: p<0.001) were significantly higher in LVAD patients than controls. Conclusions: Patients after long-term LVAD support showed a high prevalence of CMBs and superficial siderosis, and more severe WMH and cerebral atrophy compared to age- and sex-matched controls. Long-term LVAD support may cause cerebral small vessel disease.