Abstract PR414

Abstract

Background & Objectives: To discussion whether dexmedetomidine combined sevoflurane can inhibit alveolar and systemic inflammatory responses in patients undergoing one lung ventilation. Materials & Methods: Sixty-eight Patients undergoing one-lung ventilation,ASA physical statusI-II, were randomized into four groups(n=16 each): The control group(group C),dexmedetomidine group (group D),sevoflurane group(group S),dexmedetomidine combined sevoflurane group(group DS). Continuous infusion of dexmedetomidine was maintained at a rate of 0.5ug.kg-1h-1 in group D. Sevoflurane with 1 MAC was inhaled and the equal volume of normal saline was given in group S. Continuous infusion of dexmedetomidine was maintained at a rate of 0.5ug.kg-1h-1 and Sevoflurane with 1 MAC was inhaled in group DS. The equal volume of normal saline was given in group C. In four groups. Arterial blood and non-surgical bronchoalveolar lavage were collected before OLV(T1) and at the end of OLV(T2). We should observe and record perioperative hemodynamic and respiratory parameters changes. Results: The concentrations of TNF-αand IL-8 at T2 increased significantly compared to baseline(T1)in four groups. Compared with group C, the bronchoalveolar lavage and serum concentrations of TNF-α and IL-8 were significantly decreased in the other groups at T2. Compared to group D, IL-8 in alveolar lavage fluid and serum, and TNF-a in alveolar lavage fluid of group DS are significantly lower. In group S, TNF-a in serum and IL-8 in alveolar lavage fluid are significantly lower than group D. TNF-a and IL-8 in serum and alveolar lavage fluid of group DS are significantly lower than that in group S. Conclusion: Dexmedetomidine combined sevoflu- rane in patients undergoing one lung ventilation may have a synergistic effect, effectively inhibited alveolar and systemic inflammatory response after OLV. Thus providing pulmonary protection.