Abstract PR211

Abstract

Background & Objectives: We aimed to compare the effects of propofol sedation in elective cesarean sections under spinal anesthesia on maternal hemodynamics, oxygen saturation, intraoperative vasopressor requirement in mothers and Apgar score, Neonatal Infant Pain Scale(NIPS) and umbilical cord gases in newborns Materials & Methods: 60 cases that will undergo elective surgery in ASA I-II group, included in the study.Informed and written consent was obtained. Prior to spinal anesthesia, heart rate (HR), diastolic arterial pressure (DAP), systolic arterial pressure (SAP), mean arterial pressure (MAP), transdermal peripheral oxygen saturation (SaO2), intraoperative requirement of ephedrine were measured and recorded. Spinal anesthesia using 10 mg hyperbaric bupivacaine was applied in the seated position. Spinal anesthesia was administered to 30 patients without the application of any sedation (Group C) and in the other 30 cases, a single dose of 0.5 mg/kg propofol (Group P) was administered at the beginning of the anesthesia. SAP, DAP, MAP, SaO2, facial expression pain scale were recorded at five-minute intervals until the end of the operation following propofol administration. In the newborns, the Apgar score, NIPS(The scale developed for premature babies and newborns that use the facial expressions to describe the intensity of pain (1)) and umbilical cord blood gases were measured and recorded at the 1, 3, and 5th minutes. Results: DAP, SAP, MAP were similar between groups. (p>0.05) Heart rates were similar in Group C and Group P. (p=0.844) Newborn Apgar Scores and Pain Score: Median Apgar scores at minutes 1, 3, and 5 between Group C and Group P were similar (p>0.05). (Table 1) The NIPS score at minute 1 was significantly higher in Group P compared to Group C, although not clinically significant (p=0.004). The median NIPS scores at minutes 3 and 5 were statistically similar in Group C and Group P. (p=1)Umbilical Venous Blood Gases: Mean pH was similar in Group C and Group P (p=0,133). Mean PCO2 was also similar in Group C and Group P (p=0.578). The mean PO2 was similar in Group C and Group P (p=0.075). The mean HCO3 was also similar in Group C and Group P (p=0.160). The mean BE level was statistically significantly higher in Group P compared to Group C (p=0.012).Conclusion: In conclusion although propofol is considered as a safe and reliable anesthetic agent in cesarian sections we suggest that further larger studies to determine the neurologic, behavioral and pain effects of propofol on newborns are needed.