Abstract PO-128: Completion of nipple reconstruction in triple-negative breast cancer patients compared to triple-positive breast cancer patients: A single institutional analysis

Abstract

Abstract Background: Triple-negative (TN) breast cancer is considered to be more aggressive than other subtypes of breast cancer and has a poorer prognosis. It is defined as breast cancer tumors that lack estrogen receptor (ER), progesterone receptor (PR), and HER2 expression and affects 17-20% of women with breast cancer. However, reconstructive outcomes remain to be elucidated when compared to other invasive breast cancer subtypes. The aim of this study is to determine if there is a disparity in completing nipple-areolar reconstruction in breast cancer patients with a triple-negative subtype compared to patients with a triple-positive (TP) subtype. Methods: 107 patients who underwent bilateral non-nipple sparing mastectomies from 2013 to 2017 diagnosed with a TN (n = 54) and TP (n = 53) invasive breast cancer subtype were identified. All 107 patients were seen by two attending surgeons at a single institution. Completion of nipple reconstruction and areolar tattoos, number of days from mastectomy to nipple reconstruction, and areolar tattoos were analyzed. Demographic/clinical variables, including race, age, BMI, smoking, comorbidities, neoadjuvant/adjuvant chemotherapy, hormonal therapy, radiation therapy, and choice of implants or flaps were also analyzed. Results: There was no significant difference in the proportion of patients who underwent radiation therapy in the TN group than in the TP group (55.56% vs 37.74%, p = 0.0819). Among these two groups, there was no significant difference in the percentage of patients completing nipple reconstruction (TN = 44.44%, TP = 49.06%, p = 0.7001) and acquiring an areolar tattoo (TN = 33.33%, TP = 39.62%, p = 0.5503). The differences in the average duration in days from mastectomy to nipple reconstruction (TN = 505.7, TP = 456.4, p = 0.5259) and areolar tattoos (TN = 665.6, TP = 638.5, p = 0.7653) among these two patient populations were also insignificant. Conclusion: TN subtype does not make a significant impact on completing nipple reconstruction when compared to TP patients, another extreme. These results should be considered when counseling TN patients on their reconstructive journey. Citation Format: Joshua Amaya, Kaitlin Jones, Nicholas T. Haddock, Sumeet S. Teotia. Completion of nipple reconstruction in triple-negative breast cancer patients compared to triple-positive breast cancer patients: A single institutional analysis [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-128.