Abstract PD-023: CORRELATION OF MEAN PLATELET VOLUME WITH PELOD-2 SCORE AS A PROGNOSTIC FACTOR OF SEPSIS IN CHILDREN

Abstract

Aims & Objectives: Sepsis is a clinical condition of organ dysfunction that potentially life-threatening. Pediatric Logistic Organ Dysfunction 2 (PELOD-2) score is used to assess organ dysfunction and predict mortality in patient with sepsis. Recently, many studies has been conducted to investigate mean platelet volume (MPV) as indicator of sepsis. MPV that represent platelet size, function and activation is usually reported in complete blood count. This study aims to correlate MPV value with PELOD-2 score as prognostic factor in pediatric patients with sepsis. Methods Cross-sectional study was conducted on sepsis children in H. Adam Malik Hospital and University of Sumatera Utara Hospital. Evaluation of MPV value and PELOD-2 score was conducted on the first day and 72 hours after sepsis was diagnosed. Results 43 subjects were recruited in this study. Median value of MPV at 0 hour and 72 hours was 9.8 (8.2 – 12.8) fL and 10.7 (8.5 – 13.8) fL, respectively. The increased score of PELOD-2 had strong correlation with increased value of MPV (p <0,001, r 0,668). MPV value measured at 72 hours had better performance rather than MPV value at 0 hour (AUC 94,3%, p < 0.001 vs AUC 78.7%, p = 0.001) to predict mortality, with cut-off point of 10.8 fL reached sensitivity 81% and specificity 81,8%. Conclusions MPV value has correlation with PELOD-2 score as a prognostic factor in pediatric patients with sepsis and also associated with mortality.