Relationship between Procalcitonin and C-Reactive Protein on Pelod Score in Pediatric Surgery Sepsis Patients at Dr Soetomo General Hospital Surabaya

Abstract

The incidence of sepsis in the world was estimated around 1.8 million cases / year , whereas 25-38% ofthem requiring treatment in intensive care unit , with mortality of 1,400 cases / day . In Indonesia, child’smortality rate due to sepsis is still very high, around 50% -70%, and if accompanied with septic shock andmultiple organs dysfunction, the rate is increased (80%) . One of the scoring system that can describe theseverity degree of multiple organs dysfunction in children is PELOD (Pediatric Logistic Organ Dysfunction)score. But this assessment is time consuming, because many parameters that have to be calculated. One ofthe ways to shorten the time is by using diagnostic markers such as procalcitonin (PCT) and C-ReactiveProtein (CRP).Method: The research is a study of analytic observational to determine the relationship between PELODscore with a value of procalcitonin and CRP in patients of children with sepsis and determine the cutoff pointof procalcitonin and CRP can be associated with incidence of septic shock. Research carried out for threemonths started in January 2020 until April 2020. Patients who meet the criteria for inclusion and exclusionrequested approval. Laboratory blood tests were done from day 1-3 of the sepsis.Results: In the study it was obtained the result that the age of majority is in the category of 5-10 years thatas many as 11 patients (36.7%). In the category of the type of sex the most are men - men that 19 patients(63.3%) and patients mostly great suffering sepsis that 23 patients (76.7%). Analysis between CRP withPELOD Score by using the chi-square test , the obtained results that there is a relationship that significantbetween CRP with PELOD Sc ore on a day to 1-3 with a value of p value of each 0,001 ( p < 0,05) ; 0.002( p < 0.05) ; 0.004 ( p < 0.05), which means that there is significant relationship between CRP with PELODScore . Analysis between PCT with PELOD Score by using the chi-square test , the obtained results thatthere is a relationship that significant between PCT with PELOD Score on a day to 1-3 with a value ofp value respectively 0.005 ( p < 0,05) ; 0.001 ( p> 0.05) ; 0.016 ( p> 0.05), which means that there is arelationship which is significantly meaningful between PCT with PELOD Score. In research it obtained thevalue of the boundary between the groups of patients with sepsis with shock, sepsis is Pelod score value of29 is the boundary between groups of sepsis and shock, sepsis, CRP value of 88 is the boundary betweengroups of sepsis and shock, sepsis, PCT value 9 is the boundary between groups of sepsis and shock sepsis .Conclusion: There is a significant relationship between the PCT with PELOD Score and significantrelationship between the CRP with PELOD Score.