Abstract P4-05-04: Menopausal breast cancer: Bone mineral density (BMD) and prognostic factors

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Abstract Aims: Study the relationship between Bone Mineral Density (BMD) before breast cancer and prognostic factors in menopausal breast cancerMethods: Study 340 menopausal breast cancer, BMD before breast cancer and prognostic factors. The bone mineral density was measured using z score femur of dual energy X-ray absorptiometry (DXA), z score was classified between > 1 - < -1 and > -1. Analyze z score with the prognostic factors (tumor size T1 versus T2-3, nodes positive versus negative, histologic grade I vs II-III, hormonal receptor positive versus negative, HER2 positive versus negative, Ki 67 > 20 versus <20, p53 positive versus negative), tumor subtype (Luminal versus No Luminal), bilateral tumor (synchronous, asynchronous) and recurrences. Results: The mean age of the 340 patients was 61 years. Score femur of dual energy X-ray absorptiometry (DXA) was > 1 - < -1 in 284 (84'41%) and > -1 - -3'8 in 53 (15'58) patients. Tumor size was greater than 2 centimeters in 55 16.17%) patients and in 285 (83.82%) patients up to 2 centimeters. Histological Grade (HG) was I in 196 (57.64%), II in 121/35.58) and III in 23 (6.76%) patients. The. z score femur of dual energy X-ray absorptiometry (DXA) was> 1 - < -1 in 284 (84'41%) patients and> -1 - -3'8 in 53 (15'58) patients. Tumor size was greater than 2 centimeters in 55 (16.17%) patients and in 285 (83.82%) patients up to 2 centimeters. Histological Grade (HG) was I in 196 (57.64%), II in 121/35.58) and III in 23 (6.76%) patients. The tumor subtype was Luminal A in 276 (82.65%), Luminal B HER2- in 64 (18.87%), Luminal B HER2 + in 26 (7.66%), HER2 + in 12 (3.52%). and Triple Negative in 12 (3.53%) patients. Recurrences were in. 14 patients. The z score of dual energy X-ray absorptiometry (DXA) before breast cancer > +1 - < -1 was related (p<0'05) to HG I, T1, Luminal tumor subtypes and HER2+ tumor subtypes. It is not related (p=ns) to positive nodes, hormonal receptors (HR), Ki 67, p53 positive and bilateral synchronous and asynchronous tumor. Conclusion. The z score of dual energy X-ray absorptiometry (DXA) before breast cancer can give us information on the prognostic factors of menopausal breast cancer Citation Format: Menopausal breast cancer: Bone mineral density (BMD) and prognostic factors [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P4-05-04.