Abstract P3017: Associations of Metabolic Syndrome, Diabetes, and Metabolic Syndrome Plus Diabetes With Extent of Intracranial Atherosclerotic Stenosis

Abstract

Background and Objective: Metabolic syndrome (MetS) plus diabetes mellitus (DM) are linked to higher recurrent stroke risk (vs. MetS only). With varying MetS definitions, we compared the extent of intracranial atherosclerotic stenosis (ICAS) defined as >/=50% stenosis among ischemic stroke patients with different MetS and DM status. Methods: We conducted a cross-sectional study of 1158 Korean patients with acute ischemic stroke (mean age 68.3±12.7; 43.3% female), who underwent brain MRI and MRA. Patients were stratified into MetS only, DM only, both, and neither. MetS was defined using the harmonized and International Diabetes Foundation (IDF) criteria. Results: Results of the multivariable adjusted associations between MetS status and ICAS appear in Figure 1. Patients with MetS (harmonized and IDF) plus DM had a higher prevalence of ICAS and more ICAS lesions vs. those with neither condition ( p <0.001 for all). Compared with neither condition, harmonized MetS plus DM was independently associated with higher ICAS lesions (OR 2.15 95% CI; 1.15–4.01 for ICAS >/=2 and OR 3.07, 95% CI; 1.25–7.50 for ICAS >/=3) and IDF MetS plus DM also showed a similar pattern to findings from harmonized definition. Conclusion: MetS plus DM remained an independent predictor of ICAS burden, which might be linked to an intracranial atherogenic stroke. These findings support to identify patients with MetS at high risk of developing DM who might benefit from greater scrutiny and more intensive life style modification to prevent from ICAS extension.