Abstract P289: Gender Differences in Rates of Stroke in Patients With Hypertrophic Obstructive Cardiomyopathy With and Without Atrial Fibrillation

Abstract

Introduction: Stroke is a known complication of hypertrophic obstructive cardiomyopathy (HOCM) and this complication is more common in patients with accompanying atrial fibrillation (AF). However, data regarding gender related differences with respect to this complication is sparse. Objective: We sought to understand the gender differences in rates of stroke in patients with HOCM with and without AF. Methods: The Nationwide Inpatient Sample was queried from 2010 to 2014 using ICD-9 codes 425.1 and 425.11 for HOCM in all diagnosis fields. AF was identified by ICD-9 code 427.31. We excluded patients with an indicator for transfer to another acute-care facility to reduce the possibility of data duplication. Chi-square was used for statistical analysis. Results: From 2010 to 2014, we identified 73,347 patients with HOCM (Mean age 63.76 ± 16.5 years; females 59% and Caucasians 67.5%). The overall rate of ischemic stroke in this cohort was 2153 (2.9%). Rate of ischemic stroke between males and females was similar (2.9% vs 3%; p <0.001). AF was present in 26,393 (36%), male vs female (39.4% vs 33.7%; p <0.001). Overall, prevalence of stroke in HOCM patients with and without AF was significant 3.5% vs 2.6%; p<0.001. Between males and females, the rates of stroke in HOCM patients with and without AF were not different (3.5% vs 3.5%, p =0.4 and 2.4% vs 2.7%; p =0.9). Conclusion: Although stroke rates were higher in HOCM patients with AF, stroke rates were similar in both genders of HOCM patients with and without AF. It is important to consider anticoagulation in these patients to reduce the risk of stroke.