Abstract P247: Non-dipping Ambulatory Blood Pressure in Non-hypertensive Individuals

Abstract

Non-dipping predicts increased cardiovascular risk in hypertension. However, the mechanisms leading to non-dipping remain unknown. Also, non-dipping in normotension and prehypertension is less well-described. The study objective was to determine the prevalence of non-dipping, and the association of non-dipping with other cardiovascular risk factors, in non-hypertensive young adults. The study cohort included 176 non-hypertensive, non-diabetic individuals, mean age 27 ( Table 1 ). Office and 24-hour ambulatory BP were measured, along with fasting adipokine levels, insulin sensitivity (QUICKI) and measures of vascular stiffness: Ambulatory arterial stiffness index (AASI) and pulse pressure. The distribution of dipping patterns was 58% dippers, 35% non-dippers, 5% extreme dipping, and 2% reverse dipping. CRP, IL6, and AASI are significantly associated with non-dipping ( Table 2 ). Non-dipping in common in young non-hypertensive adults. Inflammation and vascular stiffness may be potential mechanisms explaining the increased cardiovascular risk associated with non-dipping.