Abstract P2-14-21: Adjuvant chemotherapy-associated lipid changes in breast cancer patients: A retrospective analysis

Abstract

Abstract Background: Adjuvant chemotherapy may cause alterations in serum lipids in postoperative breast cancer (BC) patients, but the specific alterations caused by different chemotherapy modalities remain unclear. The aim of this study was to investigate the status of serum lipids pre- and post-chemotherapy and to compare lipid level alterations among different chemotherapy modalities. Methods: We retrospectively analysed the lipid profiles of 1934 consecutive postoperative BC patients who received one of the following chemotherapy modalities: doxorubicin and cyclophosphamide followed by paclitaxel (AC-T); epirubicin and cyclophosphamide followed by paclitaxel (EC-T); cyclophosphamide and paclitaxel (TC); and fluorouracil, cyclophosphamide and epirubicin (FEC). Results: The levels of triglycerides (TGs), total cholesterol (TC) and low-density lipoprotein (LDL) were significantly elevated in patients who received chemotherapy (p<0.01). With respect to different chemotherapy modalities, AC-T elevated the lipid profiles more than FEC in premenopausal patients (p<0.05), while in postmenopausal patients, FEC had the smallest effects in terms of high-density lipoprotein (HDL) and LDL compared with the effects of other chemotherapy modalities (p<0.05). In addition, premenopausal BC patients had a higher incidence of dyslipidaemia (18.84%) after chemotherapy than postmenopausal BC patients (12.27%). Moreover, after adjusting for multiple baseline covariates, AC-T chemotherapy modality was still statistically associated with a high level of TGs after chemotherapy. Conclusions: BC patients receiving chemotherapy may have a high risk of dyslipidaemia, but the effects vary with different chemotherapy modalities. Therefore, it is necessary to take lipid metabolism into consideration when making chemotherapy decisions and to monitor serum lipids regularly during chemotherapy.Key words: Breast cancer; Adjuvant chemotherapy; Dyslipidaemia Citation Format: Tao He, Yunhao Wu, Xinyi Zhang, Jie Chen. Adjuvant chemotherapy-associated lipid changes in breast cancer patients: A retrospective analysis [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P2-14-21.