Abstract
Aim: We hypothesized that alterations in the expression and phosphorylation of abdominal aorta protein networks contribute to arterial remodeling in age-dependent hypertension (HTN). Methods: Mean arterial pressure (MAP) and blood pressure variability (BPV) were measured by femoral artery cannulation in 3- and 16-month-old (mo) male Sprague-Dawley (SD) rats (N=4/group). Quantitative proteomic/phosphoproteomic analysis was performed on individual abdominal aorta. The differentially expressed/phosphorylated proteins identified at 3 vs. 16-mo (
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