Abstract No.: ABS1288: A multicentric research study on correlation between covid 19 vaccination status and severity of disease

Abstract

Background & Aims:To correlate the severity of coronavirus disease (COVID) with vaccination status in COVID 19 pandemics. The Primary Objective of the present study was to know occurrence of Post vaccination breakthrough infections in hospitalized patients and the Secondary Objective was to assess the severity of COVID-19 infection amongst vaccinated patients.Methods:The present study was a retrospective observational multicentric study performed on 325 covid positive patients admitted in High dependency units (HDUs) and Intensive care units (ICUs) and were either on Non rebreather mask (NRBM) or Bilevel positive airway pressure (Bipap) or invasive Ventilation. These patients were then divided as per severity of their symptoms into severe or non severe in correlation with their vaccination status. The study included covid positive as well as High resolution computed tomography (HRCT) thorax suggestive of covid ground glass appearance with age above 18 years and excluded patients who developed adverse reaction post vaccination, pediatric age group, pregnant and lactating females.Mild Symptoms VS Vaccination Symptoms1st Dose2nd DoseNo Doseχ2 test statistics (P)Fever60717127.08 (0.040)Headache516Cold20027Weakness301102Dry cough1085177Runny nose10124Body ache17033Sore Throat000Loss of smell and taste14221Results:Total 325 confirmed covid positive patients were studied. Statistical analysis was done with SPSS version 26 and data were analysed by Chi-square test & P value< 0.05 was considered as significant. Total duration of hospital stay was less in vaccinated patients compared to non vaccinated patients and also oxygen requirement was much less in vaccinated patients. The severity of covid infection was also less in vaccinated than amongst non vaccinated.Conclusion:Covid 19 vaccination is very effective in preventing severity of infection.