Abstract
Abstract Cells within tumours have diverse genomes, epigenomes, and interact differentially with their surrounding microenvironment generating intratumour heterogeneity, which has critical implications for treating cancer patients. I will present our current approach to understand the intratumour heterogeneity in glioblastoma through the analysis of patient-derived models. I will present examples of how we perform functional analysis to understand genomic alterations in the context of inter- and intra-tumoral heterogeneity taking special interest on their therapeutic implications. Linked to the concept of intratumor heterogeneity in the cellular state of differentiation, I will explain our studies related to cancer-initiating cells in glioblastoma, and I will focus on the TGF-beta pathway which has a critical role in glioblastoma. Citation Format: Joan Seoane. Intratumoral heterogeneity in glioblastoma. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr IA17. doi:10.1158/1538-7445.CHTME14-IA17
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