Abstract
Abstract The fibroblasts of mouse skin connective tissue arise from two distinct lineages during embryonic development. One forms the upper dermis, including the dermal papilla, dermal sheath and arrector pili muscle, and is required for hair follicle formation. The other forms the lower dermis, including the reticular fibroblasts that synthesize the bulk of the fibrillar ECM, and the skin adipocyte layer. The lower dermal lineage is responsible for the first phase wound repair. We have been investigating the changes in the composition of adult mouse dermis when epidermal tumors arise through oncogenic beta-catenin activation. Our studies highlight the contribution of different fibroblast subpopulations to the stroma of skin tumors. Citation Format: Fiona M. Watt. Fibroblast heterogeneity in skin tumour stroma. [abstract]. In: Proceedings of the AACR Special Conference: Function of Tumor Microenvironment in Cancer Progression; 2016 Jan 7–10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2016;76(15 Suppl):Abstract nr IA03.
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