Abstract
Abstract The widespread use of high-throughput genomic methods is profoundly changing the way we understand, classify, and treat cancers, and provides unprecedented opportunities to design therapeutic approaches tailored to individual patients. The success of these efforts is contingent on our ability to identify, among the hundreds of different genetic lesions, those that actively drive tumorigenesis. The recent development of powerful genome editing methods promises to greatly speed up this process and allows us, for the first time, to model a wide range of previously inaccessible cancer-associated mutations. I will discuss how CRISPR-based gene editing methods are revolutionizing cancer. I will also show how my group is combining computational methods and in vivo somatic genome editing approaches to generate and characterize novel mouse models of human cancers and to explore the noncoding fraction of the cancer genome. Citation Format: Andrea Ventura. Cancer modeling in the CRISPR age [abstract]. In: Proceedings of the AACR Special Conference: Advances in Modeling Cancer in Mice: Technology, Biology, and Beyond; 2017 Sep 24-27; Orlando, Florida. Philadelphia (PA): AACR; Cancer Res 2018;78(10 Suppl):Abstract nr IA03.
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