Abstract
Abstract The next-generation sequencing of tumors is providing an increasingly detailed description of the molecular alterations that occur across the diversity of human cancers. An important and challenging next step is to convert this wealth of information into new therapeutic hypotheses to guide patient care. My laboratory integrates cancer genomics, experimental functional genomics and mechanistic studies to elucidate vulnerabilities operative in cancer cells. These efforts are part of our Cancer Dependency Map initiative which aims to assign a dependency to every cancer cell in a patient and which could be exploited to develop new therapies (https://depmap.sanger.ac.uk/). In my presentation, I will discuss recent results from my laboratory and how these are shaping our understanding of the landscape of targetable dependencies in cancer cells. Citation Format: Mathew Garnett. Functional genomics approaches to identify targetable dependencies in cancer cells [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; 2019 Oct 26-30; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2019;18(12 Suppl):Abstract nr CN03-02. doi:10.1158/1535-7163.TARG-19-CN03-02
Published Version
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