Abstract B72: Clinical and morphological traits of patients with triple-negative breast cancer

Abstract

Abstract Background: Breast cancer (BC) is the most prevalent cause of mortality from cancer in women aged 40-69 years in Russian Federation. There are results of clinical researches about triple negative BC [ER(-); PR(-); HER2/neu (-)]. Materials and Methods: The register consisted of 1428 Caucasian women with BC aged 20-79 years (756 — familial and 672 — sporadic BC), control group composed 1581 Caucasian women aged 19-84 years without of cancer. The questioning including data of pheno- and genotype. BRCA or other mutations were performed to all patients. The researching morphological traits of tumor were histological type, estrogen receptor (ER), progesterone receptor (PR) and HER2/neu. Results: Triple negative BC was found out by 21 BRCA positive patients, 32 BRCA negative patients and 27 patients with sporadic BC. Some of reproductive and clinical factors differed in two groups: triple negative and non-triple negative BC. Among triple negative BC patients, women with sporadic BC were older and had clinical stage higher. Specific gravity of rare tumors was higher by patients with BRCA mutations. Conclusion: The women with BC can be divided into two groups: having triple negative phenotype and all the rest. Considering these factors let us prognosticate progress notes and form an individual plan of special treatment. Citation Information: Cancer Prev Res 2010;3(12 Suppl):B72.