Abstract
Abstract Traditional Chinese Medicine (TCM) compositions usually comprise multiple herbs and components that interact. In the present report, the TCM mixture LQ (gavage, 600 mg/kg/day) significantly inhibited lung cancer primary tumor growth and metastasis suggesting selective targets. LQ was efficacious against primary and metastatic cancer without weight loss in contrast to cyclophosphamide and doxorubicin, which caused significant weight loss. Survival of tumor-bearing mice was also prolonged by LQ comparable to doxorubicin. Cancer cell apoptosis was selectively induced by LQ. The results indicate that LQ can have non-toxic efficacy against metastatic lung cancer in clinically relevant orthotopic mouse and experimental metastasis models of cancer. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):B171. Citation Format: Lei Zhang, Chengyu Wu, Yong Zhang, Fang Liu, Xiaoen Wang, Ming Zhao, Robert M. Hoffman. Traditional Chinese medicine (TCM) herbal mixture LQ targets lung cancer metastasis. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr B171.
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