Abstract A011: Evaluation of a theory-informed video intervention to educate underrepresented groups on clinical and genomic research using the Theoretical Framework of Acceptability

Abstract

Abstract Introduction: Emerging evidence supports the potential effectiveness of technologically based interventions to disseminate health information to underserved populations. Considering the multifactorial barriers to clinical trial and genomic testing participation especially for African Americans (AA), who have been shown to make up less than 10% of all cancer clinical trial participants, a video was developed to inform minority populations on the importance of diversity in clinical trials and genomic research. To confirm that the video was deemed acceptable by the target audience, a quantitative assessment was conducted. Methods: We utilized the Theoretical Framework of Acceptability to create a survey aimed at assessing the animated video. Participants viewed the video and were asked to fill out the survey. Thirty-seven surveys were completed which included members of a patient advisory council at a local hospital (n=6) and graduate students from a medical school (n=29). Results: Responses were recorded on a five-point Likert scale ranging from 1 (Strongly Disagree) to 5 (Strongly Agree). Participants agreed that they enjoyed viewing the illustrations in the video (𝑋̅=4.32, s=0.97) and listening to the audio (𝑋̅=4.22, s=1.03). After watching the video, participants reported that it educated them on what a “genome” is (𝑋̅=4.16, s=0.83), as well as the benefits of participating in a clinical trial (𝑋̅=4.62, s=0.49) and donating biospecimens (𝑋̅=4.14, s=0.95). Participants moderately agreed that the video informed them on the disadvantages of participation in a clinical trial (𝑋̅=3.38 s=1.36) and biospecimen donation (𝑋̅=3.70, s=1.10). Participants reported feeling confident in making well-informed decisions about participating in clinical trials (𝑋̅=4.27, s=0.69) or donating biospecimens after watching the video (𝑋̅=4.24, s=0.80). However, after watching the video participants reported being somewhat unclear on how to sign up for a clinical trial (𝑋̅=3.57, s=1.21) and how to donate biospecimens (𝑋̅=3.43, s=1.21). Overall, the video was inclusive of the participants’ beliefs and values (𝑋̅=4.24, s=0.76) and attitudes towards the video were favorable with a mean score of 4.4 (s=0.62) on a scale from 1 (Completely Unacceptable) to 5 (Completely Acceptable). Discussion: The feedback received through the TFA adapted questionnaire will be utilized to improve the content of the video. Health communication methods should consider creating technologically based interventions that are deemed acceptable by target populations, in order to engage with and educate underrepresented populations. Citation Format: Victoria Churchill, Jamirah Y. Chevrin, Roland Matthews, Brian Rivers. Evaluation of a theory-informed video intervention to educate underrepresented groups on clinical and genomic research using the Theoretical Framework of Acceptability [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr A011.