Abstract 9964: Clinical Impact of Handgrip Strength on Prognosis After Percutaneous Coronary Intervention

Abstract

Introduction: Sarcopenia is defined as age-related loss of skeletal muscle mass and strength, and has been reportedly associated with cardiovascular disease. However, the impact of handgrip strength (HGS) on clinical outcomes after percutaneous coronary intervention (PCI) in patients with coronary artery disease has not been well investigated. Methods: This was a retrospective, single center, observational study. A total of 469 patients who underwent PCI were included. Periprocedural HGS of both hands were measured and of which better value was used for assessment. Patients were divided into 2 groups, low HGS group (men;<28kg, women;<18kg) and high HGS group (men;≥28kg, women;≥18kg) according to the consensus of Asian Working Group for Sarcopenia. The primary outcome was the composite endpoint of all-cause death, myocardial infarction, and heart failure readmission. Results: There were 151 patients in the low HGS group and 318 patients in the high HGS group. The age of patients in the low HGS group was significantly higher (78 [71-82] vs. 70 [61-75] years, p<0.001), while the body mass index and serum albumin level were significantly lower than those in the high HGS group. During the median follow-up period of 778 days, composite endpoint occurred in 35 patients with low HGS and 29 patients with high HGS. The low HGS group had a higher incidence of composite endpoint than the high HGS group (p<0.001) (Figure). The low HGS group had a higher risk of individuals of all-cause, cardiac, and non-cardiac death (p<0.001, respectively). Multivariate Cox proportional hazards analysis showed that low HGS was an independent predictor for the composite endpoint (HR 1.86, 95% CI 1.04-3.33, p=0.04). Conclusions: Low HGS was independently related with long-term cardiac events after PCI.