Abstract 9501: Duration of Ideal Cardiovascular Health With Risk of Chronic Kidney Disease and Cardiovascular Disease

Abstract

Introduction: Increasing number of clinical guidelines are adopting comprehensive cardiovascular risk assessment tools for treatment decision and disease management in the context of primary and secondary prevention. Yet, little is known regarding the exact cardiovascular risks associated with length of favorable cardiometabolic health sustenance in midlife. Methods: From the Korean Genome and Epidemiology Study Ansung-Ansan cohort, we included 7,854 middle-aged adults without chronic kidney disease and 7,796 without cardiovascular disease at baseline. Duration of ideal cardiovascular health was the sum of time spent with ideal body mass index, blood pressure, fasting glucose, total cholesterol, non-smoking, alcohol drinking, and physical activity levels. We employed Cox proportional hazards model to assess chronic kidney disease and cardiovascular events risks. Results: The median age of the participants was 50.0 years and 47.9% were male. Over a median follow-up of 15.0 years, 1,401 new chronic kidney disease and 493 new cardiovascular disease occurred. With <5 years group as the reference, multivariable-adjusted hazard ratios [95% confidence intervals] for chronic kidney disease were 0.63 [0.39-0.93] with 5 to 10 years and 0.33 [0.15-0.74] with ≥10 years of ideal cardiovascular health ( P trend, 0.0057). Similarly, participants lived with longer ideal cardiovascular health had significantly lower cardiovascular disease (5 to 10 years, 0.83 [0.54-1.27]; ≥10 years, 0.22 [0.08-0.60]). Subtype-specific analyses indicated negatively graded risks for coronary artery disease ( P trend, 0.0239) and cerebrovascular disease ( P trend, 0.0514). Conclusions: Our findings confer that maintaining favorable health behaviors and clinical cardiometabolic profile in midlife will improve later-life cardiovascular outcomes.