Abstract 9167: Relationship Between Dietary Vitamin D Intake, Obesity, and Twenty Lipoprotein Subclasses: Results from the Kyushu and Okinawa Population Study

Abstract

Introduction: The correlation between serum vitamin D deficiency, obesity, and various diseases has been reported, however, there were few investigations on the role of dietary vitamin D intake on obesity and dyslipidemia. Objective: To examine whether dietary vitamin D intake affects obesity and dyslipidemia. Methods: Dietary vitamin D intake amounts calculated using obtained data of food frequency questionnaire and 20 lipoprotein cholesterol and triglycerides subclasses using gel permeation high performance liquid chromatography were analyzed in 945 men and women (mean age 58.3 years, free of thyroid or chronic liver diseases and off osteoporosis, cholesterol lowering, or adrenocorticosteroid medications). Univariate and multivariate regression, and partial correlation analyses were performed to examine the associations between dietary vitamin D intake, obesity, and lipoprotein subclasses. Results: Dietary vitamin D intake had a significant negative association with body mass index in both post- and pre-menopausal women groups ( r = -0.1053 and -0.1761, P = 0.02 and 0.04, respectively). Regarding 20 lipoprotein subclasses, dietary vitamin D intake were negatively associated with very low-density lipoprotein-3 cholesterol in premenopausal women ( r = -0.2099, P =0.02) and positively associated with total high-density lipoprotein (HDL) cholesterol in men ( r = 0.1159, P = 0.04). In addition, dietary vitamin D intake also showed a marginally positive correlation with total HDL cholesterol in premenopausal women ( r = 0.1323, P = 0.13). Those association were also found in the frequency of fish intake, a major source of vitamin D in Japan. Conclusions: Our results indicate that proactive dietary vitamin D intake may help prevent or eliminate obesity and dyslipidemia.