Abstract P112: Association between sleep duration and serum lipid levels in an elderly Korean population: The Korean Urban and Rural Elderly (KURE) Study

Abstract

Importance: Sleep duration has been considered as a risk factor for cardiometabolic disease and mortality. Several studies suggest that sleep duration can influence the serum lipid levels, but the association remains unclear. Objective: The aim of present study is to assess the association of sleep duration with serum lipid levels in an elderly Korean population. Methods: The KURE study is a cohort study to investigate risk factors for major disorders of the elderly. This cross-sectional analysis was conducted among 926 participants (302 men and 624 women aged 64-87 years) who completed baseline health examination in 2012. Sleep duration was measured by the interviewer-assisted questionnaire. Habitual sleep time was calculated based on the response to the questions about hour of bedtime, hour of rising, and hours of nap during the passing year. Total cholesterol, triglyceride and high density lipoprotein (HDL) cholesterol concentrations in serum were measured from overnight fasting blood samples. Low density lipoprotein (LDL) cholesterol was calculated from total cholesterol, HDL cholesterol and triglyceride levels using Friedewald’s formula. Multiple linear regression models were conducted to examine whether sleep duration was associated with serum lipid levels. Results: Sleep duration was not significantly associated with total cholesterol (β=-0.154mg/dL per sleep hour, p =0.843), triglyceride (β=-1.000, p =0.506) and LDL cholesterol (β=0.678, p =0.339) after adjusting for age, sex, body mass index, systolic blood pressure, tobacco smoking, alcohol intake, physical activity, diabetes mellitus, myocardial infarction and stroke. However sleep duration was inversely associated with HDL cholesterol (β=-0.644, p =0.015) in fully adjusted model. In the sex-specific analysis, sleep duration was marginally associated with HDL cholesterol in men (β=-0.770, p =0.078) and significantly associated with HDL cholesterol in women (β=-0.685, p =0.037) after fully adjustment. Conclusions: Our findings suggest that longer sleep duration was associated with lower serum HDL cholesterol level in an elderly Korean population. Keywords: Sleep duration, lipids, HDL cholesterol, elderly