Abstract 9077: Long-Term Prognostic Value of Controlling Nutritional Status Score and Six-Minute Walk Distance in Patients With Implantable Cardioverter Defibrillator

Abstract

Backgrounds: Both Controlling Nutritional Status (CONUT) score and 6-minute walk distance (6MWD) provide prognostic information in patients with chronic heart failure. However, there is little information available on long-term prognostic value of CONUT score and 6MWD for the prediction of severe ventricular tachyarrhythmias and cardiac death in implantable cardioverter defibrillator (ICD) patients. Methods and Results: We prospectively enrolled 233 consecutive outpatients with ICD (age: 66±14 years, male: 82%, NYHA class: 1.7±0.7, LVEF: 47±17%). At entry, laboratory data and 6MWD were obtained in all patients. During a follow-up period of 4.3±2.8 years, 75 patients had appropriate ICD discharge for severe ventricular tachyarrhythmias and 45 patients had cardiac death. At multivariate Cox regression analysis, 6MWD was significantly and independently associated with appropriate ICD discharge after adjustment with age, sex, NYHA class and LVEF, while CONUT score was not. Patients with short 6MWD (≤300m) had a higher risk of appropriate ICD discharge (42 % vs 23%, p=0.0002). On the other hand, at multivariate Cox regression analysis, CONUT score was significantly and independently associated with cardiac death after adjustment with age, sex, NYHA class and LVEF, while 6MWD showed the association with cardiac death at univariate analysis. Patients with higher CONUT score (≥4) had a higher risk of cardiac death (35% vs 15%, p<0.0001). Conclusions: CONUT score would be associated with cardiac death, while 6MWD might be associated with appropriate ICD discharge, in patients with ICD.