Abstract 87: Urinary LDH activities in patients with Kawasaki disease

Abstract

Background: Kawasaki disease (KD) is a systemic vasculitis with unknown origin. KD patients often have leukocytes in urine as well as urinary tract infection (UTI). The aim of this study is to evaluate urinary LDH and its isozyme, which is useful in diagnosis with UTI, in patients with KD. Patients and methods: 158 patients with KD (including 4 with incomplete KD) and 52 patients with febrile sickness were enrolled as control group in this study. Urine samples were obtained at least one point. Results: Total level of urinary LDH in patients with KD was significantly higher than that in control group. Urinary LDH level in the acute phase was significantly higher than that with convalescent phase in patients with KD. Urinary LDH isozyme showed predominant elevations of LDH1 and LDH2. Some patients showed the elevation of urinary LDH level before the clinical criteria of KD were fulfilled. There was no correlation between urinary LDH concentration and pyuria. Conclusion: The levels of LDH isozyme (LDH4 and LDH5) in urine is known to increase in patients with acute upper urinary tract infection, while the level of its isozyme (LDH1 and LDH2) increased in acute phase of KD. The elevated levels of total urinary LDH and its isozyme (LDH1 and LDH2) may be useful for early diagnosis of KD and also for diagnosis of incomplete KD.