Abstract 784: NCI CPTAC phase III, proteogenomic analysis of 10 cancers

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Abstract The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) is an international effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteomic and genomic analysis, or proteogenomics. Leidos Biomedical Research, a prime contractor to NCI, provides a robust infrastructure for supporting the collection and sequencing of high-quality biospecimens and data, in addition to project and subcontract management for this program. CPTAC applies the understanding of the molecular basis of cancer to identify biomarker candidates. CPTAC phase III began late 2016 to collect and analyze 200 cases of each of ten additional cancers. The cancers include sarcoma, pancreatic ductal adenocarcinoma, head and neck squamous cell carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, uterine corpus endometrial carcinoma, clear cell renal cell carcinoma, glioblastoma multiforme, and acute myeloid leukemia. The program completed the discovery phase collection of 100 cases for 3 tumor types in the first year. The study entails collection and pathology evaluation of biospecimens, high-quality clinical data and images from clinical sites around the world. A biorepository evaluates and processes the biospecimens, sending nucleic acids to sequencing centers and tissues to proteomics groups. Data are combined and analyzed by proteogenomic data analysis and translational centers. Genomic data are made available to the research community through the NCI Genomic Data Commons. Proteomic and proteogenomic data are made available through the Data Coordinating Center. Imaging data are made available through NCI imaging archive. We report here on progress in collection of tissues and clinical data, the preliminary analysis trends and the integration of biorepository, proteomics and genomics and analysis centers. Citation Format: Mathangi Thiagarajan. NCI CPTAC phase III, proteogenomic analysis of 10 cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 784.