Abstract
Abstract Background: The role of obesity, physical activity and weight gain in renal cell carcinoma (RCC) has not been well understood. Given the crucial role of PI3K-AKT-mTOR pathway (or mTOR pathway) plays in metabolism, cell growth and tumorigenesis, it is important to evaluate the joint effect of genetic variants in this pathway and energy balance risk factors for RCC. Methods: In this case-control study, 577 Caucasian cases and 593 Caucasian healthy controls were included in the analyses. Cases and controls were frequency-matched by age (±5 years), gender and county of residence. Epidemiological data were collected via in-person interview. Genotyping data of 157 SNPs was extracted from previous GWAS which has been done using Illumina HumanHap660K/610K BeadChips in the laboratory. Unconditional logistic regression was used to calculate odds ratios and their 95% confidence interval (CI). Results: Obesity at age 20, age 40 and 3 years prior to the diagnosis or recruitment were each significantly associated with increased RCC risk. Moderate (10.1-25 lbs) and massive weight gains (>25 lbs) from age 20 to 40 increased RCC risk by 46% (95%CI: 1.16-2.34) and 62% (95%CI: 1.10-2.39), respectively. Low physical activity was associated with 4.08-fold (95%CI: 2.92-5.70) of increased RCC risk. Three SNPs had significant association and their cumulative effect had increased the risk up to 85% (OR: 1.85, 95%CI: 1.28-2.68). When considering multiple risk factors, subjects who were overweight or obese, experienced weight gain during adulthood (>10 lbs), had history of hypertension and unfavorable genotypes in mTOR pathway had 12.84-fold increased risk (95%CI: 5.08-32.46) of RCC. Conclusion: Our results provided strong evidence that energy balance risk factors and genetic variants in mTOR pathway could jointly influence the susceptibility to RCC. Our findings have implications on RCC prevention if confirmed in future independent studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 673. doi:1538-7445.AM2012-673
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