Abstract
Abstract Objective: Previous studies suggest a positive association between history of non-melanoma skin cancer (NMSC) and risk of subsequent cancer development. We prospectively investigate this association in both men and women. Methods: In two large cohorts in the US, the Health Professionals Follow-up Study (HPFS) and the Nurses’ Health Study (NHS), we prospectively examined the risks of primary cancer according to history of NMSC. In the HPFS, 876,094 person-years were followed up from June 1986 to June 2008. In the NHS, 2,358,185 person-years were followed up from June 1984 to June 2008. We documented 30,636 cancer cases after ongoing NMSC diagnosis. The median time (and range) of diagnosis between NMSC and subsequent cancer was 156 (3 - 342) months in the NHS, and 116 (3 - 259) months in the HPFS. Cox proportional hazard models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs), adjusting for major cancer risk factors (e.g. age, smoking, body mass index, physical activity, etc). Results: A history of NMSC was associated with a higher risk of other primary cancers in men (RR = 1.15; 95% CI: 1.08, 1.21; P < 0.0001), and in women (RR = 1.25; 95% CI: 1.20, 1.31; P < 0.0001). For individual cancer sites, in men, a history of NMSC was associated with an increased risk of prostate cancer, non-Hodgkin lymphoma, and melanoma. In women, a history of NMSC was associated with an increased risk of breast cancer, endometrial cancer, ovarian cancer, lung cancer, non-Hodgkin lymphoma, renal cancer, melanoma, and oral cancer. Conclusions: Our prospective-cohort study provides evidence for an association between a history of NMSC and an increased risk of subsequent malignancies. Further studies are warranted to identify the potential mechanism underlying this relationship. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 636. doi:1538-7445.AM2012-636
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