Abstract
Abstract Natural killer (NK) cells are play pivotal functions in the tumor microenvironment of cancer immune surveillance. The killing ability of NK cells is expected to contribute to death of cancer cell. To prove NK cells as a cell therapy, we frist manufactured NK cells from the peripheral blood of healthy donor who received informed consent in a GMP facility. And we verifed the killing ability of the NK cells by decreasing the size of the tumor in NOG mice inoculated with SKBR3, HER2-positive breast-cancer cell, into mammary fat pad (orthotopic models). In this study, sudden death of mice was not found even when 20 millions NK cells were injected into a NOG female with intravenous injection. Moreover, it was confirmed that the size of the tumor was significantly reduced after NK cell injection. It is necessary to study co-administration with a targeted therapy such as rastuzumab and pertuzumab, and NK cells as a cell therapy will help reduce the size of the tumor. In the future, additional research is needed on the combined administration of targeted therapeutics and NK cells. Citation Format: Chaok Yim, Jun Woo Lee, Jin-Hee Kim. Antitumor effect of natural killer cells on breast cancer cells in murine model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6012.
Published Version
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