Abstract
Abstract In previous studies among 1,144 cases and 1,256 controls recruited in the Stage I Shanghai Breast Cancer Study (SBCS-I), 18 known or potentially functional single nucleotide polymorphisms (SNPs) in 16 genes were found to be associated with breast cancer risk. The authors evaluated these associations among 1,918 cases and 1,819 controls recruited in the Stage II SBCS (SBCS-II) using genetic effect models and subgroup analyses pre-determined from SBCS-I results. Five SNPs showed generally consistent results in SBCS-I and SBCS-II and statistically significant associations with breast cancer risk in combined analyses (AHR rs2066853, ATM rs1003623, ESR1 rs2234693, GSTP1 rs1695, and SHBG rs6259), mostly in subgroups defined by age or menopausal status. Further, the relation between breast cancer risk and SHBG rs6259 was found to vary by body mass index (BMI) (P-value for interaction = 0.003). The strongest reduction in risk associated with SHBG rs6259 was found for postmenopausal lean (BMI<23) minor allele carriers (Odds Ratio=0.6; 95% Confidence Interval: 0.5, 0.8; P-value = 4.6×10−4). This biologically plausible and highly significant finding provides strong evidence for a true association among Asian women. This study also highlights the value of gene-environment interaction analyses in evaluating genetic factors for complex diseases. Abbreviations: BMI, body mass index; CI, confidence interval; OR, odds ratio; SBCS, Shanghai Breast Cancer Study; SNP, single nucleotide polymorphism. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5597. doi:10.1158/1538-7445.AM2011-5597
Published Version
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