Abstract
Background: The prevalence of isolated (one lipid disorder) and mixed (≥2 lipid disorders) dyslipidemia has not been well-chararacterized, particularly among patients with coronary heart disease (CHD) and type 2 diabetes mellitus (DM). We examined the association between types of dyslipidemia and CHD or DM among a representative sample of US adults. Methods: We studied 2,827 adults with complete lipid data for LDL-C, HDL-C and triglycerides (TG) representing 126 million US adults in the National Health and Nutrition Examination Survey (NHANES) 2003–2004. We determined the prevalence of elevated LDL-C (as per NCEP guidelines), low HDL-C (<40 mg/dL for men and <50 mg/dL for women) and/or elevated TG (≥200 mg/dL) among those with CHD (n=134) or DM (n=277). Multivariate logistic regression examined the association between CHD or DM and types of dyslipidemia while controlling for clinical and demographic characteristics. Results: Overall, 74% with CHD and 80% of those with DM had ≥1 lipid disorder. Among CHD patients, 60%, 27% and 27% had elevated LDL-C, low HDL-C and elevated TG respectively, while 20% had 2 lipid disorders and 10% had all 3. Among DM patients, 65%, 40% and 22% had elevated LDL-C, low HDL-C, and elevated TG respectively, while 29% had 2 lipid disorders and 10% had all 3. Compared to those with no lipid disorder, the odds of CHD were 4–6 times greater with elevated LDL-C combined with elevated TG regardless of HDL-C. In contrast, the odds of DM were the greatest in those with elevated LDL-C and low HDL-C regardless of TG. Other types of dyslipidemia were less strongly or not associated with CHD or DM (Table ). Conclusions: In this representative sample of US adults, CHD was most closely associated with elevated LDL-C combined with elevated TG regardless of HDL-C levels, while DM was most closely associated with elevated LDL-C and low HDL-C regardless of TG levels. These differences should be considered when choosing therapies for dyslipidemia in patients with CHD and DM. Multivariable Adjusted Odds of Coronary Heart Disease (CHD) or Diabetes (DM) by Lipid Disorder
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call