Abstract 5242: To investigate the molecular mechanism and therapeutic roles of PSF-1 in leukemia

Abstract

Abstract Recently, DNA replication protein PSF-1 gets more and more attention on the research field, PSF-1 not only plays the critical role in normal cell DNA replication but also involves in cancer cell proliferation and anti-apoptosis. PSF1 highly expressed in many types of cancers, such as non-small lung cancer, breast cancer, and colon carcinoma. However, the role and mechanism of PSF1 in leukemia are still uncleared. Compared to the human normal peripheral blood mononuclear cells (PBMCs), the expression level of PSF1 was significantly increased in several types of leukemia, including acute and chronic type leukemia. We also found that PSF1 participate in leukemic cell proliferation and anti-apoptosis. Since PSF1 presents in many types of leukemia, PSF-1 might act as a potential therapeutic target of pan-leukemia. However, in order to enhance the therapeutic effect of leukemia, against its recurrence and metastasis, leukemic stem cells (LSCs) become the novel therapeutic research target. Previous studies indicated that PSF-1 is essential for stem cell proliferation. Based on the study, we selected PSF-1 as the candidate. In this research, we would like to investigate the role of PSF-1 in leukemia and its cancer stem cell niche. Further to establish the new therapeutic method of LSC-specific clinical treatment. Citation Format: Han-Yun Hsieh, Wei-Zhen Jia, Nobuyuki Takakura. To investigate the molecular mechanism and therapeutic roles of PSF-1 in leukemia [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5242.