Abstract 5209: Trends in a survival of cancer of the coupus uteri in Japan 1993-2006 (J-CANSIS)

Abstract

Abstract The incidence of cancer of the corpus uteri (CC) in Japan is continuously increasing. To explore the trend in a survival of Japanese CC, we analyzed the population-based cancer registry data. We obtained data on 8,562 CC cases from six prefectural cancer registries. We defined two periods as 1993-2001 (1st period) and 2002-2006 (2nd period). Relative survival (RS) of each period was calculated using cohort analysis, and we compared them using excess mortality model adjusted for age categories and extent of disease. We also estimated RS by age group, extent of disease and histological subtype. For age groups, patients were classified into those aged 15-54, 55-69 and 70-99. For extent of disease, patients were classified into those staged localized, regional and distant group. For histological subgroups, patients were divided into eight histological categories according to ‘Cancer Incidence in Five Continents Vol.10’ partially modified. The 5-year RS was 78.1% in the 1st period and 80.1% in the 2nd period. Compared with the RS in the 1st period, RS in the 2nd period was significantly high [Excess Hazard Ratio (EHR): 0.805, 95%Confidence Interval (95%CI): 0.723-0.896, P<0.001]. In the stratified analysis by age group, the 5-year RS of age group 55-69 significantly improved from 74.4% to 79.8% (EHR: 0.751, 95%CI: 0.643-0.877, P<0.001). The 5-year RS in the other age group did not improved dramatically, but the 1-year RS of age group 70 years or older had a trend towards improvement from 81.2% to 83.4% (EHR: 0.777, 95%CI: 0.586-1.029, P = 0.079). The stratified analysis by extent of disease indicated that the 5-year RS improved significantly in local disease from 93.0% to 95.2% (EHR: 0.717, 95%CI: 0.554-0.927, P = 0.011) and regional disease from 57.3% to 64.2% (EHR: 0.813, 95%CI: 0.692-0.955, P = 0.012). Among distant cases, only 1-year RS improved significantly from 46.1% to 57.1% (EHR: 0.715, 95%CI: 0.572-0.895, P = 0.003). According to the analysis by histological subgroup, the 5-year RS of endometrioid adenocarcinoma significantly improved from 85.2% in the 1st period to 90.0% in the 2nd period (EHR: 0.700, 95%CI: 0.564-0.870, P = 0.001). In the cases of other specified adenocarcinoma and carcinoma, 1-year RS improved significantly from 84.6% in the 1st period to 89.2% in the 2nd period, but 5-year RS did not. In conclusion, we could reveal the improved prognosis of Japanese CC from the period of 1993-2001 to the period of 2002-2006, using population-based cancer registry data. The improvement of short-term RS was observed among elderly, distant or non-endometriod cases, whereas their long-term prognosis did not change during the study period. Improved prognosis might be attributed to the progress of treatment, especially due to chemotherapy or formulation of treatment guidelines in early 2000’s. Citation Format: Shusaku Inoue, Satoyo Hosono, Hidemi Ito, Isao Oze, Yoshikazu Nishino, Masakazu Hattori, Akiko Ioka, Tomio Nakayama, Keitato Matsuo, Mika Mizuno, Kiyoko Kato, Hideo Tanaka, Yuri Ito. Trends in a survival of cancer of the coupus uteri in Japan 1993-2006 (J-CANSIS). [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 5209.