ABSTRACT 514

Abstract

Background and aims: Maternal and prenatal factors such as maternal diseases, micronutrient deficiency and teratogen exposure may cause to congenital abnormalities. Aims: We aimed to investigate the relation between maternal and neonatal mikronutrient levels and CHD. Methods: This prospective study was conducted in a tertiary NICU of Turkey between May 2013 and December 2013. The newborns born at 35–42 weeks of gestational age and diagnosed as CHD were included. Healthy newborns were assigned as controls. The mothers of the subjects were also included. Maternal and neonatal characteristics of the subjects were recorded. Micronutrient (folat, homocysteine, zinc, vitamin A, vitamin D, and vitamin B12) levels were detected in all subjects. The study was approved by local ethics committee. Results: A total of 72 subjects (study group: n=47 and control group: n=25) were included. The mean gestational age and birthweight were 38,5 ± 1,6 wk and 3145 ± 509 g respectively. Study patients and controls did not differ in terms of sociodemographic characteristics. Maternal homocysteine and zinc level were higher and vitamin D level was lower in the study group compared to controls. Neonatal homocysteine levels were also higher in the study group, although not significantly. Other micronutrient levels did not differ between the groups. Conclusions: Maternal and neonatal micronutrient levels may have role in the pathogenesis of CHD.