Abstract 5008: The potential role of hsa-miR-3157-3p in prostate cancer pathogenesis

Abstract

Abstract Prostate cancer remains a major area of concern as it is the second leading cause of cancer mortalities amongst American men. Our study aimed to find the role of differentially expressed microRNAs that play a role in prostate cancer etiopathology. With the use of the National Center for Biotechnology Information (NCBI), we narrowed down a desired dataset (GSE138740). While analyzing the dataset, we found the expression pattern of hsa-miR-3157-3p (adjusted p-value 0.04797) to be significantly upregulated in low grade tumor samples (Gleason Score 6 and n=88) compared to high grade tumor samples (Gleason Score 8,9 and n=13). Furthermore, the role of hsa-miR-3157-3p in prostate cancer remains a novel finding. We have identified target genes such as E2F3, UBE2M, ABCF1, PKN3 and VANGL1 using the RNA Central website portal. Further studies are underway to elucidate the expression pattern of this miRNA and it’s target genes that would correlate with the disease progression observed among tumor samples in The Cancer Genome Atlas (TCGA) database. The Ingenuity Pathway Analysis (IPA) software generated report will be presented at the meeting to describe gene networks and pathways implicated in Prostate Cancer. Overall, these studies are designed to further validate whether this miRNA and its target genes can serve as potential biomarkers to predict the onset and progression from low to high grade prostate cancer. Citation Format: Akhil Wali, Hari Koul. The potential role of hsa-miR-3157-3p in prostate cancer pathogenesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5008.