Abstract
Abstract Synthetic oligonucleotides (ODNs) containing specific sequences have an immunomodulatory effect. It is highly expected that such ODNs can be developed into a novel anti-cancer immunotherapy with these effects. Our past data revealed that a novel poly-G ODN has an anti-tumor immune effect in the tumor-bearing murine model. This effect of poly-G ODN was mediated by T cells in a TLR9 independent manner. Poly-G ODN directly induced the phosphorylation of Lck, thereby enhancing the production of IL-2 and T cell proliferation. Meanwhile, our recent data suggested that the immune effect by poly-G ODN against cancer was different in human. We identified poly-G ODN induced T cell proliferation and production of IFN-gamma through the enhancement of monocyte maturation in human mononuclear cells isolated from peripheral blood or malignant pleural effusion of lung cancer patients. Further studies are continued for the establishment of a novel anti-cancer immune therapy with poly-G ODN. Citation Format: Nobuaki Kobayashi, Yuji Shibata, Masaki Yamamoto, Takashi Sato, Masaharu Shinkai, Harumi Koizumi, Kenichi Takahashi, Makoto Kudo, Hidekazu Shirota, Takeshi Kaneko. Poly G oligonucleotide enhances anti-tumor immune response among the patients with primary lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4700. doi:10.1158/1538-7445.AM2017-4700
Published Version
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