Abstract 449: Detection of some selected tumor markers in people from River Nile State - Sudan

Abstract

Abstract This study was designed to use some selected tumor markers (TMs) as screening tool to discover new cancer cases, and to use these TMs as diagnostic tool for early detection of cancer. The study area is the River Nile State with an area of 122100 Km2 and population of 1026000 persons. The national cancer control program was initiated in 1982 with WHO help, and updated in the early 1990s based on the new WHO guidelines. In 2010 the National Cancer Registry was established but still more efforts are needed to register all cancer cases in such a poor country like Sudan. According to Federal Ministry of Health (FMOH) 2008 data; cancer was ranked as the fourth cause of death in hospitals. Five hundred and ten blood samples were collected from healthy people living in River Nile State; 305 samples were males. (PSA) was measured in all males, (CA125) was used for ovarian cancer in females, (CA15-3) was used for breast cancer in females, and (CEA) Carcino Embryonic Antigen was used for colon cancer in both genders. Samples were measured using RIA technique. Written consent was obtained from all volunteers. There was an elevation in blood level of CEA in 26 samples (6.37%), two of them died during the study, 7 (2.29%) males had PSA concentrations above the upper limit, 5 (2.45%) females showed high CA15-3 concentrations, and increase in CA125 in 6 samples (2.94%). Out of the 510 subjects there were 56 samples (10.98%) had family history with cancer, and only 6 of them (10.71%) showed elevated concentrations. Most of these people are very poor and hospitals are not accessible and the diagnosis and treatment services are not affordable. Table 1 shows the concentrations for the selected TMs.The FMOH documented in 2007 that more than 345 cancer patients came from River Nile State, more cases were reported in other studies e.g. 2899 cancer incidences in Northern Sudan in 2006. In the present study, (8.63%) of the studied population showed elevated concentrations of the selected TMs. Table 1: TMs concentrations. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 449. doi:1538-7445.AM2012-449