Abstract
Abstract The Jackson Laboratory Repository is an established resource for the importation, cryopreservation, development, and distribution of mouse strains vital to biomedical research. More than 500 new strains are added annually to the approximately 5,000 strains and stocks of mice currently held in the Repository collection. Newly acquired or developed strains include a model of malignant melanoma and metastasis; a xenotransplant model that provides continuous circulation of human growth factors; a targeted mutation strain for studying myeloproliferative diseases such as chronic myelomonocytic leukemia and Chronic Familial Myelocytic Leukemia-Like Syndrome; and a knock-in strain that mimics the t(9;11)(p22;q23) translocation identified in acute myeloid leukemia. Also under development are a transgenic/targeted mutation strain with increased mammary gland tumor incidence and three targeted mutation strains with increased sensitivity to carcinogens or radiation. The Repository's inducible and conditional mutation mouse strains allow researchers to generate temporal and/or tissue-specific tools for modeling human cancer. New additions to the Repository collection include strains with Cre recombinase expression specific to the colon and rectum, as well as a transgenic strain that can be used as part of a bitransgenic system utilizing the tetracycline-inducible expression of a gene of interest in blood vessel endothelial cells. For non-invasive in-vivo imaging studies, the Repository distributes a xenograft/transplant host with widespread expression of firefly luciferase and enhanced green fluorescence protein. The Repository maintains a searchable on-line resource (www.jax.org) for each strain. Researchers can submit their strains to be considered for inclusion in the Repository by using the on-line form available at The Jackson Laboratory website: http://www.jax.org/grc/index.html. The Jackson Laboratory Repository is supported by the NCRR, The Howard Hughes Medical Institute, The Ellison Medical Foundation and donations from private charitable foundations. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4303. doi:10.1158/1538-7445.AM2011-4303
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