Abstract
Abstract Myeloid-Derived Suppressor Cells (MDSCs) are a population of immune cells that negatively regulate immune responses, which could promote tumor invasion and metastasis. Recently research has revealed that tumor could actively reshape the immune-microenvironment for its progression. We recently demonstrated that KPNA2 is a candidate oncogene in ovarian cancer that was closely related to MDSCs density, and found there was a positive position feedback between KPNA2 expressed and MDSCs density, which might contribute to the poor prognosis of patients. Based on these results, we combined clinical sample analysis, animal model and experimental studies to do further molecular and genomic research. The conduction of this project will help explain the molecular mechanisms of how KPNA2 regulates ovarian cancer through suppressing the immune system, and provide new strategies by molecular targeted therapy combining biological therapy for ovarian cancer. Note: This abstract was not presented at the meeting. Citation Format: Shuting Huang, Min Zheng, Yuanzhong Wu. Regulation mechanism and clinical significance of KPNA2 promotes MDSCs infiltrating in epithelial ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3986. doi:10.1158/1538-7445.AM2017-3986
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
