Abstract
Abstract Osteonectin/SPARC(Secreted Protein Acidic and Rich in Cysteine)/BM-40 is an extracellular protein that has been studied in ECM(Extra Cellular Matrix) organization, immune modulation, proliferation, adhesion, invasion and migration in various cancers. Advanced prostate cancer (PCa) is significantly affected by cross-talk among cancer cells, stromal cells and ECM. Such communication is particularly could contribute to migration and invasion of prostate cancer cells. However, the precise mechanism in migration and invasion of PCa cells are poorly understood. In this report, we investigated the effect of osteonectin on proliferation, migration and invasion of PCa cells. Indeed, Prostate-derived stromal cells (PrSC) has been shown to express high mRNA levels of osteonectin and secret relatively high levels of osteonectin. We revealed that osteonectin from PrSC and refined osteonectin protein also inhibited activation of AKT-p21 signaling, which plays an important role in prostate cancer cell growth, and affected down-regulation of migration and invasion of LNCaP cells. Together, these studies support a conclusion that interaction of stromal cells and PCa cells as osteonectin play an important role in progression of prostate cancer. Citation Format: Minkyoung Shin. Osteonectin suppresses proliferation and migration of human prostate cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3800. doi:10.1158/1538-7445.AM2013-3800
Published Version
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