Abstract 378: The Cancer Genome Collaboratory

Abstract

Abstract The Cancer Genome Collaboratory is an academic compute cloud designed to enable computational research on the world’s largest and most comprehensive cancer genome dataset, the International Cancer Genome Consortium (ICGC). The ICGC is on target to categorize the genomes of 25,000 tumors by 2018. A subproject of ICGC, the PanCancer Analysis of Whole Genomes (PCAWG) alone has generated over 800TB of harmonized sequence alignments, variants and interpreted data from over 2,800 cancer patients. A dataset of this size requires months to download and significant resources to store and process. By making the ICGC data available in cloud compute form in the Collaboratory, researchers can bring their analysis methods to the cloud, yielding benefits from the high availability, scalability and economy offered by cloud services, avoiding a large investment in static compute resources and essentially eliminating the time needed to download the data. To facilitate the computational analysis on the ICGC data, the Collaboratory has developed software solutions that are optimized for typical cancer genomics workloads, including well tested and accurate genome aligners and somatic variant calling pipelines. We have developed a simple to use, but fast and secure, data transfer tool that imports genomic data from cloud object storage into the user’s compute instances. Because a growing number of cancer datasets have restrictions on their storage locations, it is important to have software solutions that are interoperable across multiple cloud environments. We have successfully demonstrated interoperability across The Cancer Genome Atlas (TCGA) dataset hosted at University of Chicago’s Bionimbus Protected Data Cloud, the ICGC dataset hosted at the Collaboratory, and ICGC datasets stored in the Amazon Web Services (AWS) S3 storage. Lastly, we have developed a non-intrusive user authorization system that allows the Collaboratory to authenticate against the ICGC Data Access Compliance Office (DACO) when researchers require access to controlled tier data. We anticipate that our software solutions will be implemented on additional commercial and academic clouds. The Collaboratory is actively growing, with a target hardware infrastructure of over 3000 CPU cores and 15 petabytes of raw storage. As of November 2016, the Collaboratory holds information on 2,000 ICGC PCAWG donors (500TB total). We anticipate expanding the Collaboratory to host the entire ICGC dataset of 25,000 donors (approximately 5PB) and to extend its data management and analysis facilities across multiple clouds. During the current closed beta phase, the Collaboratory has been successfully utilized by multiple research groups, most notably PCAWG project researchers who analyzed thousands of genomes at scale over a few weeks’ time. The Collaboratory will open to the public during the second quarter of 2017. We invite cancer researchers to learn more about our cloud resources at cancercollaboratory.org, and apply for access to the Collaboratory. Citation Format: Christina K. Yung, George L. Mihaiescu, Bob Tiernay, Junjun Zhang, Francois Gerthoffert, Andy Yang, Jared Baker, Guillaume Bourque, Paul C. Boutros, Bartha M. Knoppers, BF Francis Ouellette, Cenk Sahinalp, Sohrab P. Shah, Vincent Ferretti, Lincoln D. Stein. The Cancer Genome Collaboratory [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 378. doi:10.1158/1538-7445.AM2017-378