Abstract
Abstract The International Cancer Genome Consortium (ICGC) was established to bring together researchers from around the globe to comprehensively analyze the genomic, transcriptomic, and epigenomic changes in 50 different tumour types or subtypes that are of clinical and societal importance across the globe (International network of cancer genome projects. Nature 464, 993-998 (15 April 2010)). As of December 2014, the ICGC has received commitments from researchers and funding organizations in Asia, Australia, Europe, North America and South America for 77 project teams in 17 jurisdictions to study more than 25,000 tumour genomes. More than 27,000 tumours that meet ICGC requirements for consent have been obtained and research pathologists have approved over 27,000 samples as meeting ICGC standards. Processed data is available via the Data Coordination Centre (http://dcc.icgc.org) based at the Ontario Institute for Cancer Research and is updated quarterly. The data release (Version 17) in October 2014 included datasets from 42 ICGC members. The ICGC Data Portal has been improved to provide enhanced support to the research community browsing this vast dataset. The ICGC and The Cancer Genome Atlas (TCGA) PanCancer Analysis of Whole Genomes (PCAWG) project is committing more than 2,500 tumour-normal whole genome pairs from 23 different tumour types to uniform alignment and variant calling. More than 600 researchers will contribute to the interpretation of the data and writing of papers that will focus on specific analyses covering: Identification of driver mutations outside coding regions, including those that affect cis-regulatory regions and non-coding RNAs; and identification of gene regulatory pathways altered by non-coding mutations. Because the projected size of the pan-cancer dataset for 5,000 WGS is very large, PCAWG is using a distributed compute cloud environment (at different computing centres in the USA, Europe and Asia) that meet technical requirements of the project and the bioethical framework of ICGC and its member projects. More information can be found on www.icgc.org. Citation Format: Jennifer L. Jennings, Thomas J. Hudson. International cancer genome consortium (ICGC). [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2988. doi:10.1158/1538-7445.AM2015-2988
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