Abstract 3631: Infiltrating Bruton’s tyrosine kinase expressed B cells effects on prostate cancer metastasis

Abstract

Abstract Prostate cancer is the most common type of cancer found in senior males and is the 2nd leading cause of cancer death in American males. Although prostate cancer grows slowly within the prostate glands, because of a lack of efficient treatments at the appropriate timing, cancer cells eventually become aggressive and metastatic. The progression of cancer is supported by many factors, such as signals received from surrounding cells, like B cells and other effector cells. B cells play a role as a part of the adaptive immune system to produce antibodies. To become mature B cells, they rely on activation of a non-receptor kinase, Bruton’s Tyrosine Kinase (BTK). Preliminary data from our lab showed that in the prostate cancer tissues, more infiltrated B cells expressing BTK were present nearby the prostate cancer cells. Upon this finding, we hypothesize that BTK expressed B cells will support the survival of prostate cancer cells through BTK signaling. In this study, we will overexpress BTK in B cells to study the proliferation and migration of prostate cancer cells through a co-culture system. Our findings will show an increase in migration of prostate cancer cells when cultured with BTK expressed B cells. In the future, we will validate the importance of BTK in regulating prostate cancer migration and invasion; and identify their mechanisms. Our overall findings from this project would reveal key elements of the signaling pathways of BTK expressed B cells to promote prostate cancer migration. Citation Format: Crystal Byrd, Geou- Yarh Liou. Infiltrating Bruton’s tyrosine kinase expressed B cells effects on prostate cancer metastasis. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3631.