Abstract
Background: Newer concepts & mechanisms in the pathogenesis of Type 2 Diabetes Mellitus are being explored constantly and could provide new insights into the disease and might facilitate better management. Irisin is one such molecule and is highly expressed in skeletal muscle, heart, adipose tissue, and liver.Aims and Objectives: To estimate the circulating levels of Irisin in patients with Type 2 Diabetes Mellitus. To compare the levels of serum Irisin in patients with type 2 Diabetes Mellitus with non-Diabetic controls. To study the Correlation of Serum Irisin levels with clinical, anthropometric and biochemical parameters.Results: Mean serum irisin level in Type 2 Diabetes mellitus (n=43) is 26.38±6.33 ng/ml and 59.12±42.03 ng/ml in non diabetic individuals (n=43). Serum irisin levels strongly correlated with weight, BMI, waist circumference, W/H ratio, Triglycerides, fasting plasma glucose & insulin, HOMA IR, QUICKI and HOMA betaConclusion: Serum Irisin levels were increased in obese non-diabetic subjects, while decreased in Type 2 Diabetes mellitus patients. Moreover, serum Irisin levels correlated with various anthropometric and metabolic parameters of obesity and T2DM. Irisin could be explored as a therapeutic target in Type 2 Diabetes mellitus in the future.
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