Abstract
Abstract Background: Mucins are high molecular weight glycoproteins that play important roles in carcinogenesis and tumor invasion. Several studies have shown the aberrant expression profile of mucins in gastric cancer. Claudins are the proteins that participate in the formation of tight junctions. Tight junction proteins are believed to be involved in the regulation of proliferation, differentiation, and other cellular functions. Expression of claudin family in gastric cancers has been studied by many laboratories, but the results are conflicting. Therefore, we investigated the potential of MUC and claudin family to be used as a prognostic marker in gastric cancer. Methods: One-hundred eighty gastric adenocarcinoma patients who underwent surgical resection and had not received any pre- or -post surgery therapy, were selected for this study. Among the 180 gastric cancer samples tested here, 63 (34%) were early gastric cancer, and 117 (66%) were advanced. We made tissue microarrays with paraffin-embeded formalin fixed blocks of gastric cancer and these microarrays were evaluated for phenotypic expression of MUC1, MUC4, Claudin 1, 3, 4, 5, 7 and 10 using anti-human rabbit or mouse polyclonal antibody. The expression levels were correlated with key clinicopathologic features and patient outcomes. Results: There was no significant difference of MUC and claudin expression between early and advanced gastric cancer. Gastric cancer patients with increased MUC1 expression were significantly associated with shorter overall survival as compared to those with low expression of MUC1 (log rank, p=0.039). MUC4 expression were significantly associated with decreased overall survival only in N0 patients (log rank, p=0.046). Increased expression of Claudin-10 was significantly associated with shorter disease free survival (log rank, p=0.038). Claudin 1,3,4,5 and 7 expression was not associated with significant difference of overall survival or disease free survival.Conclusion: Our present findings show that the increased expression of MUC1 and claudin-10 is a prognostic indicator of poor survival of patients with early and advanced gastric cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3161. doi:10.1158/1538-7445.AM2011-3161
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