Abstract 261: Pancreatic cancer incidence trends and recent patterns overall and by histologic type among US men and women by racial/ethnic group: evidence from the Surveillance, Epidemiology, and End Results (SEER) program

Abstract

Abstract Introduction: Pancreatic cancer incidence has been rising. We examined incidence patterns by sex, race, age, and histologic subtype. Methods: We used data from the Surveillance, Epidemiology and End Results (SEER) registries (9, 13 and 18) to calculate counts, age-adjusted rates (2000 US Standard Population), annual percent changes (APCs) and incidence rate ratios (IRRs) for all pancreatic cancers and main histologic subgroups. Results: Pancreatic cancer incidence rates declined among males between 1974 and 1991, and increased in the 1992-2013 period among white Hispanics and non-Hispanics (APC= 0.73 and 0.84, respectively). Among females, incidence rates also rose significantly during 1992-2013 among white non-Hispanics, white Hispanics, and Asians (APC= 0.81, 0.56, and 1.23, respectively). In contrast, rates among black males and females changed little. Within age groups, rates significantly increased among males who were white non-Hispanic age ≥55 years and white Hispanics in the 55-74 age group. Among black males, rates declined in the 45-54 age group at a statistically significant pace. Pancreatic cancer incidence rates for females rose among white non-Hispanics in all age groups <85 years (range: 0.47-4.01), among Asians of ages 55-84, and white Hispanics in the 55-64 age-group. Most pancreatic cancers were specified as adenocarcinoma, not otherwise specified (NOS) or ductal adenocarcinoma. Rates increased among all racial/ethnic groups for adenocarcinoma, NOS and ductal adenocarcinoma while those for cystic mucinous ductal adenocarcinoma and poorly specified type decreased. The incidence rates of non-secretory pancreatic endocrine cancer rose >6% per year among white non-Hispanics and Asian/Pacific Islanders. Overall incidence rates were significantly higher among males than females (M/F IRR=1.28). The IRR was >1.00 at all ages >35, but rates among females were significantly higher at younger ages (IRR <0.81). The M/F IRRs were elevated for acinar cell adenocarcinoma (2.85), non-secretory endocrine cancers (1.47) and ductal cystic or mucinous adenocarcinomas (1.11), while for solid pseudopapillary adenocarcinoma there was a significant female excess (0.22). Conclusion: Pancreatic cancer incidence rates vary within demographic groups and histologic subtypes. Citation Format: Vanessa L. Gordon-Dseagu, Susan Devesa, Mike Goggins, Rachael Stolzenberg-Solomon. Pancreatic cancer incidence trends and recent patterns overall and by histologic type among US men and women by racial/ethnic group: evidence from the Surveillance, Epidemiology, and End Results (SEER) program [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 261. doi:10.1158/1538-7445.AM2017-261