117 Gender and Racial Disparities in the Annual Percent Change of Incidence and Mortality Rates of Pancreatic Cancer

Abstract

INTRODUCTION: In the United States, pancreatic cancer is the fourth leading cause of cancer death for both men and women. The purpose of this study is to investigate the impact of gender, and race/ethnicity on the annual percent change of incidence and mortality rates of pancreatic cancer from 2000–2016 using the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: Patients diagnosed with pancreatic cancer from 2000–2016 were identified from the SEER Registry. We retrospectively evaluated gender-specific, and race/ethnicity variations in age-adjusted annual percent changes in incidence rates and mortality rates for people above the age above 20. We used ethnic groups consisting of White, Non-Hispanic White, Black, Asian/Pacific Islander, American Indian/Alaska Native, and Hispanic. RESULTS: Based on the SEER 21 areas data sets, the age-adjusted incidence rates of pancreatic cancer increased from 2000–2014 but remained stable from 2014–2016. The annual percent of change in incidence for both males and females from 2000–2014 was 0.9 and was −1.4 from 2014–2016. Females had an annual percent change of incidence of 0.7 from 2000 to 2016. For males, the annual percent change was 1.2 from 2000–2009 but the annual percent change from 2009–2016 was 0.2. Females had an upward trend of annual percent change of incidence rates during this period. The annual percent change of incidence by race/ethnicity can be seen in Table 1. The annual percent change in mortality rates was analyzed during 2000–2016. Females had an annual percent change of 0.2 and males had an annual percent change of 0.3. The trend of mortality rates was upward for males and females. The annual percent change of mortality rate by race/ethnicity can be seen in Table 2. CONCLUSION: The poor outcome and silent nature of pancreatic cancer necessitates the need to understand the trends associated with disease. Females had an upward trend in the annual percent change of incidence rates of pancreatic cancer from 2000–2016. There is also upward trend for annual percent change of incidence rates for Asians, Hispanics, and Non Hispanic Whites. The trend of annual percent change of mortality rates was increasing for both males and females during 2000–2016. The trend was increasing for both Non-Hispanic White and White Americans. This may support interventions to inform certain race/ethnic populations about the importance of screening for pancreatic cancer in high-risk populations.