Abstract 2492: Eradication of breast cancer with bone metastasis by autologous formalin- fixed tumor vaccine (AFTV) and radiation

Abstract

Abstract INTRODUCTION) Bone-metastatic mammary carcinoma patients show the downhill course to a tragic ending despite of intensive chemo-radiation therapy, except an our case concomitantly treated with AFTV (AACR2013, World J Surg Oncol 2013; 11:127). We here report, as the second successful case, eradication of a large bone metastasis of advanced breast cancer after treatment with AFTV and radiation. (CASE) A 47-years old female with stage II breast cancer was operated in July, 2000. Left axillar recurrence was found 13 years later by ultrasonography and FNBC. PET scan revealed a huge bone metastasis in sternum. She was treated with radiation and AFTV (J Neurosurgery 2014;4:1) in Oct. - Nov. 2013. Follow-up PET (Sep. 2014) showed no hot spot, and we diagnosed the patient, complete remission. (CONCLUSION) Complete remission of bone metastasis of mammary carcinoma is very rare. The initial successful case beared triple-negative breast cancer. Treatment with AFTV and radiation without intensive chemotherapy like the present case will be acceptable to any patient with bone-metastatic mammary carcinoma, though a large scale clinical trial should be required to confirm the therapeutic efficacy of AFTV. Citation Format: Fumito Kuranishi, Yoji Uemae, Tadao Ohno, Yusuke Sumi. Eradication of breast cancer with bone metastasis by autologous formalin- fixed tumor vaccine (AFTV) and radiation. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2492. doi:10.1158/1538-7445.AM2015-2492