Abstract 246: TGF-β1 and TGFBR2 Polymorphisms With ISH

Abstract

Background and Objective: Isolated systolic hypertension (ISH) is characterized by increased aortic stiffness and associated with a significantly increased risk of cardiovascular morbidity and mortality. It has been reported that elevated plasma transforming growth factor-beta 1(TGF-β1)levels predicted development of hypertension. However, little is known about the association of TGF- β 1 pathway gene polymorphisms and ISH. The aim of the present study was to study the association of transforming growth factor-beta 1(TGF-β1)and its receptor 2(TGFBR2)functional gene polymorphisms with isolated systolic hypertension (ISH). Methods and Results: One hundred and three consecutive ISH patients and 169 healthy controls were recruited in this study. All subjects were genotyped for TGFβ1-869T/C, TGFBR2-3779A/G and TGFBR2-1444C/G by the technology of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and then confirmed by direct sequencing. No significant difference in genotype (and allele) frequency of TGFβ1-869T/C, TGFBR2-3779A/G and TGFBR2-1444C/G polymorphisms were observed between ISH group and healthy group (p>0.05). Conclusion: Our findings suggest that TGFβ1-869T/C, TGFBR2-3779A/G and TGFBR2-1444C/G polymorphisms may not be associated with susceptibility of isolated systolic hypertension in Chinese population.